Tohoku Univ. Technology：The Treatment and Prevention of Inflammatory Bowel Disease ： T23-033
Anti-inflammatory effect by xCT inhibition or Glutamine synthetase inhibition
The limited number of drugs available for the treatment of inflammatory bowel disease(IBD) and their severe side effects, including immunosuppression, have led to calls for research into drugs without side effects. The inventors focused on the role of xCT, a cystine/glutamate antiporter, in IBD. Their research suggests that xCT inhibitors or glutamine synthetase inhibitors may be therapeutic/preventive agents for inflammatory diseases. [RESULTS] ・Mice with intestinal epithelium-specific xCT deficiency showed anti-inflammatory effects on dextran sulfate sodium(DSS) colitis(Fig.1). ・Glutamine synthetase inhibitor (MSO：Methionine sulfoximine) showed anti-inflammatory effects on DSS colitis(Fig.2).
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
